Gangliosides are the binding substances in neural cells for tetanus and botulinum toxins in mice.
نویسندگان
چکیده
We used the knockout mice lacking gangliosides and evaluated their response to tetanus and botulinum toxins. We found that tetanus toxin and botulinum type A or B toxin was less toxic in the knockout mice. We conclude that the toxins bind to the gangliosides on the synapses in the initial step of intoxication prior to penetration of the toxins into the neural cells.
منابع مشابه
Gangliosides as receptors for biological toxins: development of sensitive fluoroimmunoassays using ganglioside-bearing liposomes.
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ورودعنوان ژورنال:
- Biochimica et biophysica acta
دوره 1441 1 شماره
صفحات -
تاریخ انتشار 1999